2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-145991
    Ribavirin carboxylic acid
    		99.85%
    Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity.
    Ribavirin carboxylic acid
  • HY-W016221
    6-Hydroxy Chlorzoxazone
    		98.10%
    6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
    6-Hydroxy Chlorzoxazone
  • HY-135847
    Desmethyl ferroquine
    		98.02%
    Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains.
    Desmethyl ferroquine
  • HY-133813A
    Apovincaminic acid hydrochloride salt
    		≥98.0%
    Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action.
    Apovincaminic acid hydrochloride salt
  • HY-122440
    Scopoline
    		≥98.0%
    Scopoline (compound 3a) is a compound formed from Scopine (HY-B0459), an α1 adrenergic receptor agonist.
    Scopoline
  • HY-W008216
    HMMNI
    		99.76%
    HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class drug that combats protozoan infections.
    HMMNI
  • HY-133980A
    O-Demethyl Lenvatinib hydrochloride
    O-Demethyl Lenvatinib hydrochloride is a metabolite of Lenvatinib (HY-10981). Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET. Lenvatinib shows potent antitumor activities.
    O-Demethyl Lenvatinib hydrochloride
  • HY-124414
    4'-Hydroxytamoxifen
    		99.2%
    4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells.
    4'-Hydroxytamoxifen
  • HY-148053
    Rezivertinib analogue 1
    		99.68%
    Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer.
    Rezivertinib analogue 1
  • HY-G0022
    Doxorubicinol hydrochloride
    		≥99.0%
    Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin.
    Doxorubicinol hydrochloride
  • HY-126996
    Triiodothyronine sulfate
    		≥98.0%
    Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity.
    Triiodothyronine sulfate
  • HY-B1022
    Dimesna
    		≥98.0%
    Dimesna combined with anticancer chemotherapeutic agents to reduce nephrotoxicity.
    Dimesna
  • HY-20874
    Deschlorodemethyldiazepam
    Deschlorodemethyldiazepam is a benzodiazepines compound. Deschlorodemethyldiazepam can be hydroxylated in vitro by liver microsomal enzymes obtained from rats or mice.
    Deschlorodemethyldiazepam
  • HY-B0652
    Etonogestrel
    		99.14%
    Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).
    Etonogestrel
  • HY-W016388
    9-Fluorenol
    		99.87%
    9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 μM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo.
    9-Fluorenol
  • HY-W016034
    Acetaminophen glucuronide sodium salt
    		≥99.0%
    Acetaminophen glucuronide is a safe and effective antipyretic analgesic. Acetaminophen glucuronide is potentially toxic to liver and kidney .
    Acetaminophen glucuronide sodium salt
  • HY-17528
    Cyhalofop
    Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture.
    Cyhalofop
  • HY-117433S
    4-Hydroperoxy Cyclophosphamide-d4
    4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].
    4-Hydroperoxy Cyclophosphamide-d<sub>4</sub>
  • HY-B0199S
    Mycophenolate Mofetil-d4
    		99.47%
    Mycophenolate Mofetil-d4 is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation[1].
    Mycophenolate Mofetil-d<sub>4</sub>
  • HY-W012982S
    3-Amino-2-oxazolidinone-d4
    		99.90%
    3-Amino-2-oxazolidinone-d4 is a deuterium labeled 3-Amino-2-oxazolidinone. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as an indicator of furazolidone residues[1][2].
    3-Amino-2-oxazolidinone-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity