2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135325
    4-Hydroxyacetophenone oxime
    		99.96%
    4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic agent.
    4-Hydroxyacetophenone oxime
  • HY-B1986
    p,p'-DDE
    		99.50%
    p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM.
    p,p'-DDE
  • HY-131466
    N-Methyl Palbociclib
    		99.94%
    N-Methyl Palbociclib is an impurity of Palbociclib (HY-50767). Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor.
    N-Methyl Palbociclib
  • HY-P3147A
    IYPTNGYTR acetate
    		99.41%
    IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism.
    IYPTNGYTR acetate
  • HY-B2150
    4-Hydroxyantipyrine
    		99.9%
    4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain.
    4-Hydroxyantipyrine
  • HY-B1984
    p,p'-DDD
    		99.71%
    p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT.
    p,p'-DDD
  • HY-W008614
    Lansoprazole sulfone
    		99.52%
    Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.
    Lansoprazole sulfone
  • HY-100052
    6-Hydroxybentazon
    		99.91%
    6-Hydroxybentazon is a phase I metabolite of bentazone, and bentazone is a chemical for use in herbicides.
    6-Hydroxybentazon
  • HY-103005S
    Ramelteon metabolite M-II-d3
    		≥99.0%
    Ramelteon metabolite M-II-d3 is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].
    Ramelteon metabolite M-II-d<sub>3</sub>
  • HY-100085
    21-Desacetyldeflazacort
    		99.23%
    21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration.
    21-Desacetyldeflazacort
  • HY-135394
    3-Desacetyl Cefotaxime lactone
    3-Desacetyl Cefotaxime lactone is the active metabolite of Cefotaxime. Cefotaxime sodium salt is a third-generation cephalosporin antibiotic.
    3-Desacetyl Cefotaxime lactone
  • HY-N7686
    Paeoniflorgenin
    Paeoniflorgenin is a deglucosylated metabolite of Paeoniflorin.
    Paeoniflorgenin
  • HY-128379
    Labetalone hydrochloride
    		99.27%
    Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites.
    Labetalone hydrochloride
  • HY-113483
    20-Carboxy-Leukotriene B4
    		≥98.0%
    20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis).
    20-Carboxy-Leukotriene B4
  • HY-G0009
    Ritonavir metabolite
    		≥99.0%
    Ritonavir metabolite is a metabolite of Ritonavir, which is a HIV protease inhibitor.
    Ritonavir metabolite
  • HY-133624
    1,1,3-Tribromoacetone
    		≥98.0%
    1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    1,1,3-Tribromoacetone
  • HY-W099331
    Monoethylglycinexylidide hydrochloride
    Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation.
    Monoethylglycinexylidide hydrochloride
  • HY-126857S
    5-Hydroxy Omeprazole-d3
    		98.27%
    5-Hydroxy Omeprazole-d3 is deuterium labeled 5-Hydroxyomeprazole.
    5-Hydroxy Omeprazole-d<sub>3</sub>
  • HY-101671
    S-methyl-KE-298
    		≥98.0%
    S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
    S-methyl-KE-298
  • HY-12778
    Ivabradine metabolite N-Demethyl Ivabradine hydrochloride
    		99.63%
    N-Demethyl Ivabradine Hcl is a metabolite of Ivabradine, which is a specific inhibitor of the funny channel.
    Ivabradine metabolite N-Demethyl Ivabradine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity